河野透が、クローン病、大腸がん、抗癌剤の副作用について、最前線の医療現場の情報をお伝えします。


HOME > 河野透 研究・著書・論文

河野透の主な著書、論文等

1. Luglio G, Kono T. Surgical techniques and risk of post-operative recurrence in CD: A Game Changer? Inflamm Intest Dis 2021

2. Higashijima J, Tokunaga1 T, Yoshimoto T, Eto S, Kashihara H, Takasu C, Nishi M, Yoshikawa K, Okitsu H, Ishikawa M, Miyake H, Yagi T, Kono T, Shimada M. A multicenter phase II trial of preoperative chemoradiotherapy with S‑1 plus oxaliplatin and bevacizumab for locally advanced rectal cancer. Int J Clin Oncol 2021 doi: 10.1007/s10147-021-01868-1 PMID 33486623

3. Kono T, Fichera A. Surgical Prophylaxis of Crohn Disease Recurrence: "Light at the End of The Tunnel" Ann Surg 2020 272(2):218-219 PMID: 32675484

4. Kono T, Fichera A. Surgical treatment for Crohn’s disease: a role of Kono-S anastomosis in the West. Clin Colon Rectal Surg 2020 33(6):335-343 DOI:10.1055/s-0040-1714236

5. Sadatomi D, Kono T, Mogami S, Fujitsuka N. Weak acids induce PGE2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms. Scientific Reports 2020 10(1):20775 PMID: 33247192

6. Chen CP, Kono T, Maeda K, Fichera A. Surgical technique for intestinal Crohn’s disease. Seminars in Colorectal Surgery, 2020, 31 (2) 100744

7. Nishiyama M, Ohtake N, Kaneko A, Tsuchiya N, Imamura S, Iiduka S, Ishizawa S, Nishi A, Yamamoto M, Taketomi A, Kono T. Increase of Akkermansia muciniphila by a diet containing Japanese traditional medicine Bofutsushosan in mouse model of non-alcoholic fatty liver disease. Nutrients 2020 12(3):E839.PMID: 32245128

8. Maejima T, Kono T, Fukahori S, Yosikawa D, Karasaki H, Araki Y., Ohta T, Nagashima K. Evacuatory dysfunction after stapled hemorrhoidopexy: A case report of rectal pocket syndrome. J Anus Rectum Colon 4(2):85-88, 2020, PMID: 32346647

9. Maeda K., Katsuno H., Kono T. The Japanese extracted herbal medicine Daikenchuto increases contractile activity of the internal anal sphincter muscle in conscious dogs. J Anus Rectum Colon 2020 4(4), 193-200

10. Aoyama T., Morita S., Kono T., Hata T., Mishima H, Sakamoto J. Effects of Goshajinkigan (TJ-107) for oxaliplatin-induced peripheral neurotoxicity using the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group 12-item neurotoxicity questionnaire (FACT-GOG-NTX-12) in a phase 2, multicenter, randomized, double-blind, placebo-controlled trial. J Can Res Ther 2020

11. Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, Nagabuchi K, Asai N, Uzu M, Nonaka M, Omiya Y, Kaneko A, Ono K, Fujii H, Higami Y, Kono T, Uezono Y The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis. Sci Rep 10(1):625, 2020

12. 河野 透、前島 拓、笠井章次 クローン病手術におけるトラブルシューティング 手術 74(8)1225-1233,2020

13. 河野 透、今津嘉宏、里見眞知子 支持療法に漢方を活用するための基礎知識 臨床外科75(3)312-317,2020

14. Kono T, Shimada M, Nshi M, Morine Y, Yoshikawa K, Katsuno H, Maeda K, Koeda K, Morita S, Watanabe M, Kusano M, Sakamoto J, Saji S, Sokuoka H, Ohtake Y, Sato Y, Kenematsu T, Kitajima M. Daikenchuto accelerates recovery from prolonged postoperative ileus after open abdominal surgery: A subgroup analysis of three randomized controlled trials. Surg Today 49(8):704-711, 2019 doi: 10.1007/s00595-019-01787-9.

15. Shimada N., Ohge H., Kono T., Sugitani A., Yano R., Watadani Y., Uemura K., Murakami Y., Sueda T. Surgical recurrence at anastomotic site after bowel resection in Crohn’s disease; Comparison of Kono-S and end-to-end anastomosis. J Gastrointest Surg. 23(2), 312-319, 2019

16. Kubota K., Mase A., Matsushima H., Fujitsuka N., Yamamoto M., Morine Y., Taketomi A., Kono T., Shimada M. Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern. Neurogastroenterol Motil. 2019, 31(11):e13689 doi: 10.1111/nmo.13689

17. 河野 透、アレサンドロ フィケラ クローン病の外科治療 消化器外科42(12)1663-1677, 2019

18. 河野 透 慢性便秘症に対する漢方薬の役割 日本大腸肛門病学会雑誌72(10)615-620, 2019

19. 河野 透、前島 拓、前本篤男 小腸短腸症候群の発症要因,予防対策と対応 外科81(7)725-730, 2019

20. Miyashita T., Kono T., Matsui D., Yamazaki Y., Sadatomi D., Fujitsuka N., Nakamura S., Okamoto K., Makino I., Kinoshita J., Nakamura K., Hayashi H., Oyama K., Tajima H., Takamura H., Ninomiya I., Fushida S., Mukaisho K., Harmon JW., Ohta T. Preventive effect of oral hangeshasinto (TJ-14) on the development of reflux-induced esophageal cancer in a surgical rat model. Surgery 164(1): 49-55 2018 PMID: 29576309 21. Nishikawa K., Aoyama T., Oba M.S., Yoshikawa T., Matsuda C., Munemoto Y., Takiguchi N., Tanabe K., Nagata N., Imano M., Oshiro M., Fukushima R., Kataoka M., Morita S., Tsuburaya A., Mishima H., Kono T., Sakamoto J. The clinical impact of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: Analyses of pooled data from two phase II randomized clinical trials (HANGESHA-G and HANGESHA-C). J Cancer 9(10), 1725-1730, 2018.

22. 河野 透、前田耕太郎、坂井義治、大毛宏喜、島田光生、Alessandro Fichera、Fabrizio Michelassi Kono-S吻合 消化管吻合法バイブル 医学書院、宮澤光男、竹内裕也 編集 143p-147p,2018

23. 河野 透 末梢神経障害 副作用への漢方薬活用術 薬局 69(2), 47-52, 2018

24. 河野 透 半夏瀉心湯 漢方薬 病棟で使う順 ザ・ベストテン 月間薬事 60(3), 41-48, 2018

25. 河野 透 大建中湯 漢方薬作用機序の科学的解明 臨牀消化器内科33(11),1357-1364, 2018

26. Kono T, Shimada M, Nshi M, Morine Y, Yoshikawa K, Katsuno H, Maeda K, Koeda K, Morita S, Watanabe M, Kusano M, Sakamoto J, Saji S, Sokuoka H, Ohtake Y, Sato Y, Kenematsu T, Kitajima M. Daikenchuto administration for intestinal hypomotility after open abdominal surgery: a pooled analysis of three randomized controlled trials. Ann Cancer Res Ther 25(1), 38-39, 2017 27. Takasu C, Yismaw WG, Kurita N, Yoshikawa K, Kashihara H, Kono T, Shimada M*. TU-100 exerts a protective effect against bacterial translocation by maintaining the tight junction. Surg Today. 2017 47(10): 1287-1294. doi: 10.1007/s00595-017-1518-6. [Epub ahead of print]

28. Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang C, Yuan C, Bissonette M, Musch M, Chang E. Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer. Phytother Res. 2017 31(1):90-99. doi: 10.1002/ptr.5735.

29. Nobutani K, Miyoshi J, Musch M, Nishiyama M, Watanabe J, Kaneko A, Yamamoto M, Yoshida M, Kono T, Jeong H, Chang E. Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal. Pharmacol Res Perspect 2017 5(5): e00361 doi: 10.1002/prp2.361.

30. 河野 透、北島政樹 がん治療医のための漢方ハンドブック 漢方におけるわが国発のエビデンス 臨床外科 72(8), 912-916, 2017

31. 野崎怜雄、河野 透、 武田宏司 生薬薬理と漢方 漢方と最新治療 26(4), 285-292, 2017

32. Kono T, Fichera A, Maeda K, Sakai Y, Ohge H, Krane M, Katsuno H, Fujiya M. Kono-S anastomosis for surgical prophylaxis of anastomotic recurrence in Crohn's disease: an international multicenter study J Gastrointest Surg. 2016, 20(4), 783-790 doi: 10.1007/s11605-015-3061-3

33. Kono T, Shimada M, Yamamoto M, Kase Y. Daikenchuto and GI Disorders Herbal Medicines, Springer, Editor Akio Inui (Chapter 12), Pages 165-180, 2016

34. Tsuchiya K, Kubota K, Ohbuchi K, Kaneko A, Ohno N, Mase A, Matsushima H, Yamamoto M, Miyano K, Uezono Y, Kono T. Transient receptor potential ankyrin 1 (TRPA1) agonists improve intestinal transit in a murine model of postoperative ileus Neurogastroenterol Motil. 2016 28(12), 1792-1805 doi: 10.1111/nmo.12877.

35. Nozaki R, Kono T, Bochimoto H, Watanabe T, Oketani K, Sakamaki Y, Okubo N, Nakagawa K, Takeda H. Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells. Oncotarget, 2016 7(43):70437-70446. doi: 10.18632/oncotarget.11926.

36. Maejima T, Kono T, Orii F, Maemoto A, Furukawa S, Liming W, Kasai S, Fukahori S, Mukai N, Yoshikawa D, Karasaki H, Saito H, Nagashima K. Anal canal adenocarcinoma in a patient with long-standing Crohn’s disease arising from rectal mucosa that migrated from a previously treated rectovaginal fistula. Am J Case Rep. 2016, 17:448-453.

37. Hasebe T, Ueno N, Musch M, Nadimpalli A, Kaneko A, Kaifuchi N, Watanabe J, Yamamoto M, Inaba Y, Kono T, Fujiya M, Kohgo Y, Chang E. Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K Pharmacol Res Perspect 4(1):e00215. doi: 10.1002/prp2.215. 2016

38. Yada K, Ishibashi H, Mori H, Morine Y, Zhu C, Feng R, Kono T, Shimada M. Kampo medicine "Daikenchuto (TU-100)" prevents bacterial translocation and hepatic fibrosis in biliary atresia rat model. Surgery 159(6):1600-1611. doi: 10.1016/j.surg.2016.02.002. 2016

39. Matsuzaka S, Karasaki H, Ono Y, Ogata M, Oikawa K, Tamakawa S, Chiba S, Muraki M, Yokochi T, Funakoshi H, Kono T, Nagashima K, Mizukami Y. Tracking the Clonal Evolution of Adenosquamous Carcinoma, a Rare Variant of Intraductal Papillary Mucinous Neoplasm of the Pancreas. Pancreas 45(6):915-918. doi: 10.1097/MPA.0000000000000556. 2016

40. Higashi D, Katsuno H, Kimura H, Takahashi K, Ikeuchi H, Kono T, Nezu R, Hatakeyama K, Kameyama H, Sasaki I, Fukushima K, Watanabe K, Kusunoki M, Araki T, Maeda K, Kameoka S, Itabashi M, Nakao S, Maeda K, Ohge H, Watadani Y, Watanabe T, Sunami E, Hotokezaka M, Sugita A, Funayama Y, Futami K. Current State of and Problems Related to Cancer of the Intestinal Tract Associated with Crohn's Disease in Japan. Anticancer Res. 2016, 36(7):3761-6.

41. 河野 透、前田耕太郎、坂井義治、大毛宏喜、島田光生、Alessandro Fichera、Fabrizio Michelassi Crohn病―Kono-S法 イラストで学ぶ消化器外科再建法のすべて 外科 78(12)1413-1416, 2016

42. 河野 透、前島 拓、笠井章次、向井伸貴、深堀 晋、吉川大太郎、王 利明、唐崎秀則 クローン病に対する外科手術 INTESTINE 20(2)165-172, 2016

43. 河野 透、アレサンドロ フィケラ アトラスで学ぶ達人の手術 Crohn病の手術 外科的再狭窄予防法(Kono-S吻合)消化器外科 39(5) 604-609, 2016

44. 河野 透 大建中湯の作用メカニズム 腸管の運動促進作用と血流増加作用 漢方医学 40(2), 81-84, 2016

45. 河野 透 抗がん剤の神経障害に対する漢方薬 メビオ 33(2),18-30,2016

46. Kono T., Fichera A. Recurrent CD:Surgical Prophylaxis-Kono-S anastomosis Crohn’s Disease: Basic Principles, Springer, Editors: Fichera A., Krane M. (Eds.), Pages 227-236, 2015.

47. Kono T., Suzuki Y., Mizuno K., Miyagi C., Omiya Y., Sekine H., Mizuhara Y., Miyano K., Uezono Y. Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats. Sci Rep-Uk 2015 5:16078. doi: 10.1038/srep16078.

48. Kono, T., M. Shimada, M. Yamamoto et al (2015) Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto. Front Pharmacol 6:159. doi: 10.3389/fphar.2015.00159.

49. Matsuda C, Munemoto Y, Mishima H, Nagata N, Oshiro M, Kataoka M, Sakamoto J, Aoyama T, Morita S, Kono T. Double-blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol. 2015 76(1):97-103. doi: 10.1007/s00280-015-2767-y. PMID: 25983022

50. Suzuki T, Kono T, Bochimoto H, Hira Y, Watanabe T, Furukawa H. An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation. Sci Rep-Uk 2015 doi: 10.1038/srep07668 51. Katsuno H, Maeda K, Hanai T, Masumori K, Koide Y, Kono T. Novel antimesenteric functional end-to-end handsewn (Kono-S) anastomoses for Crohn's disease: a report of surgical procedure and short-term outcomes. Dig Surg. 2015;32(1):39-44. doi: 10.1159/000371857.

52. Sadakane C, Watanabe J, Fukutake M, Nisimura H, Maemura K, Kase Y, Kono T. Pharmacokinetic Profiles of Active Components After Oral Administration of a Kampo Medicine, Shakuyakukanzoto, to Healthy Adult Japanese Volunteers. J Pharm Sci. 2015 104(11):3952-9. doi: 10.1002/jps.24596.

53. Shimada M, Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, Kono T, Kamiyama T, Morita S, Sakamoto J, Kusano M, Saji S, Kanematsu T, Kitajima M. Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multicenter, phase III trial (JFMC40-1001) Int J Clin Oncol 2015, 20:95–104

54. Katsuno H, Maeda K, Kaiho T, Kunieda K, Funahashi K, Sakamoto J, Kono T, Hasegawa H, Furukawa Y, Imazu Y, Morita S, Watanabe M. Clinical efficacy of Daikenchuto for gastrointestinal dysfunction following colon surgery: a randomized, double-blind, multicenter, placebo-controlled study (JFMC39-0902). Jpn J Clin Oncol. 2015, 45(7):650-6.

55. Watanabe J, Kaifuchi N, Kushida H, Matsumoto T, Fukutake M, Nishiyama M, Yamamoto M, Kono T. Intestinal, portal, and peripheral profiles of daikenchuto (TU-100)'s active ingredients after oral administration. Pharmacol Res Perspect. 2015, 3(5):e00165. doi: 10.1002/prp2.165.

56. Kubota K, Ohtake N, Ohbuchi K, Mase A, Imamura S, Sudo Y, Miyano K, Yamamoto M, Kono T, Uezono Y. Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9. Am J Physiol-Gastr L. 2015 Apr 1;308(7):G579-90. doi: 10.1152/ajpgi.00114.2014.

57. Oki E, Emi Y, Kojima H, Higashijima J, Kato T, Miyake Y, Kon M, Ogata Y, Takahashi K, Ishida H, Saeki H, Sakaguchi Y, Yamanaka T, Kono T, Tomita N, Baba H, Shirabe K, Kakeji Y, Maehara Y. Preventive effect of Goshajinkigan on peripheral neurotoxicity of FOLFOX therapy (GENIUS trial): a placebo-controlled, double-blind, randomized phase III study. Int J Clin Oncol. 2015 Jan 28. PMID:25627820 58. Matsuzaka S, Karasaki H, Ono Y, Ogata M, Oikawa K, Tamakawa S, Chiba S, Muraki M, Yokochi T, Funakoshi H, Kono T, Nagashima K,Mizukami Y. Tracking the clonal evolution of adenosquamous carcinoma, a rare variant of intraductal papillary mucinous neoplasm of the pancreas. Pancreas 2015, 45(6):915-918

59. 河野 透 Crohn病に対する外科治療、Annual Review 2015消化器、233p-240p、2015竹原徹郎、金井隆典、下瀬川 徹、島田光生編集、中外医学社出版

60. 河野 透 抗がん剤の副作用に対するKampoのエビデンス 医薬ジャーナル51(2), 69-73, 2015

61. 河野 透 外科と漢方、使ってみよう漢方薬、98p-106p、2015 小野孝彦編集、文光堂出版

62. 宮野 加奈子, 河野 透, 上園 保仁 抗がん剤治療による口内炎に対する半夏瀉心湯の効果 日本薬理学雑誌146巻2号 76-80、2015

63. Kono T, Takeda H, Shimada M, Kase Y, Uezono Y. Novel therapeutics for adverse effects of antitumor therapy: the promise of multicomponent, traditional Japanese herbal remedies. J Carcinog Mutagen S8:007. doi: 10.4172/2157-2518.S8-007, 2014

64. Kono T, Kaneko A, Matsumoto C, Miyagi C, Ohbuchi K, Mizuhara Y, Miyano K, Uezono Y. Multitargeted Effects of Hangeshashinto for Treatment of Chemotherapy- Induced Oral Mucositis on Inducible Prostaglandin E2 Production in Human Oral Keratinocytes. Integr Cancer Ther. 13(5), 435-445, 2014

65. Kono T, Fichera A Kono-S anastomosis for Crohn's disease: narrative - a video vignette. Colorectal Dis 2014 16(10):833. doi: 10.1111/codi.12722.

66. Shimada M, Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, Kono T, Kamiyama T, Morita S, Sakamoto J, Kusano M, Saji S, Kanematsu T, Kitajima M. Effect of TU-100, a traditional Japanese medicine, administered after Hepatic Resection in Patients with Liver Cancer: a multi-center, randomized, double-blind, placebo-controlled phase II trial (JFMC40-1001) Int J Clin Oncol. 73(5), 1047-1054, 2014

67. Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-κB suppression Plos ONE 23;9(5):e97456. 2014 doi:10.1371/journal.pone.0097456

68. Mizuno K, Kono T, Suzuki Y, Miyagi C, Omiya Y, Miyano K, Kase Y, Uezono Y. Goshajinkigan, a traditional Japanese medicine, prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat. J Pharmacol Sci. 125(1), 91-98, 2014

69. Aoyama T, Nishikawa K, Takiguchi N, Tanabe K, Imano M, Fukushima R, Sakamoto J, Oba MS, Morita S, Kono T, Tsuburaya A. Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol. 73(5), 1047-1054, 2014

70. Watanabe K, Karasaki H, Mizukami Y, Kawamoto T, Kono T, Imai K, Einama T, Taniguchi M, Kohgo Y, Furukawa H. Cyst infection of intraductal papillary mucinous neoplasms of the pancreas: management of a rare complication: report of 2 cases. Pancreas. 43(3):478-81, 2014

71. 河野 透、前田耕太郎 坂井義治、大毛宏喜、島田光生、アレサンドロ フィケラ、ファブリッチオ ミケラッシー Crohn病に対する外科治療 切除吻合法(手縫い吻合vs器械吻合) Kono-S吻合 外科 76(3), 267-273, 2014

72. 河野 透、笠井章次、北川真吾 炎症性腸疾患の手術 消化器病診療(第2版)、医学書院、日本消化器病学会監修397-400, 2014

73. 河野 透 消化器疾患と漢方薬 炎症性腸疾患 医学と薬学71(5), 823-829, 2014

74. 河野 透 日本における伝統薬によるがん治療の現状-外科的見地から 日中医学 28(4), 14-20, 2014

75. 河野 透 便通異常 腫瘍内科 14(2), 128-135, 2014

76. Kono T, Kaneko A, Omiya Y, Ohbuchi K, Ohno N, Yamamoto M. Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin up-regulates blood flow in rat small intestine Am J Physiol-Gastr L. 304: 428-36, 2013

77. Kono T, Hata T, Morita S, Munemoto Y, Matsui T, Kojima H, Takemoto H, Fukunaga M, Nagata N, Shimada M, Sakamoto J, Mishima H Goshajinkigan Oxaliplatin Neurotoxicity Evaluation (GONE): a phase 2, multicenter, randomized, double-blind, placebo-controlled trial of goshajinkigan to prevent oxaliplatin-induced neuropathy Canc Chemother Pharmacol 72(6), 1283-1290, 2013

78. Munekage M, Ichikawa K, Kitagawa H, Uehara H, Watanabe J, Kono T, Hanazaki K. Population Pharmacokinetic Analysis of Daikenchuto, a Traditional Japanese Medicine (Kampo) in Japanese and US Health Volunteers. Drug Metab Dispos. 41: 1256-1263, 2013

79. Kaneko A, Kono T, Miura N, Tsuchiya N, Yamamoto M. Preventive effect of TU-100 on a type-2 model of colitis in mice: Possible involvement of enhancing adrenomedullin in intestinal epithelial cells. Gastro Res Pract 2013 doi:10.1155/2013/384057.

80. Sakatani A., Fujiya M, Ito T, Inaba Y, Ueno N, Kashima S, Tominaga M, Moriichi K, Okamoto K, Tanabe H, Ikuta K, Ohtake T, Kono T, Furukawa H, Ashida T, Kohgo Y. Infliximab extends the duration until the first surgery in patients with Crohn’s disease. Biomed Res Int 2013 doi:10.1155/2013/879491

81. Abe T, Kono T, Hachiro Y, Kunimoto M, Furukawa H. Risk factors for internal anal sphincter dysfunction in Japanese adults. Open J Gastroenterol. 3(1): 25-34, 2013

82. 河野 透、前田耕太郎、坂井義治、大毛宏喜、島田光生、Alessandro Fichera 腸管切除再建法:機能的端端手縫い吻合法(Kono-S吻合)手術67(9): 1259-1266, 2013 

83. 河野 透、前田耕太郎、坂井義治、大毛宏喜、Alessandro Fichera 新しい腸管吻合法:Kono-S吻合 著書名:炎症性腸疾患の外科治療 pp139-145, 2013

84. 河野 透 Crohn病の腸管病変に対する手術適応と術式の選択 消化器外科 36(1), 65-76, 2013

85. 河野 透、武田 宏司、上園保仁、島田光生 消化器外科と漢方  消化器外科 36(8),1299-1305, 2013

86. 河野 透 消化器疾患に対する漢方医療の実際 イレウス 臨床消化器内科 28(2),189-196, 2013

87. 河野 透、上園保仁、武田宏司、笠井章次、佐藤宏彦、島田光生 オキサリプラチンによるしびれ-牛車腎気丸 臨床外科68(12), 1319-1323, 2013

88. 河野 透、武田 宏司、上園保仁 外科医のためのKampo EBM UP-TO DATE 抗癌剤の副作用と漢方薬 日本外科学会雑誌 114(5), 251-255, 2013

89. 前田耕太郎、勝野秀稔、河野 透 外科医のためのKampo EBM UP-TO DATE 周術期における大建中湯の有用性と作用メカニズム114(5), 232-235, 2013

90. 河野 透、海老澤 良昭、千里直之、北川真吾、古川博之 機能温存手術の適応と限界 炎症性腸疾患における機能温存手術の適応と限界 北海道外科雑誌57(2), 20-25, 2013

91. 河野 透 周術期における漢方薬の応用 序論 漢方と最新治療 22(2), 91-93, 2013

92. Kono T, Asama T, Chisato N, Ebisawa Y, Okayama T, Imai K, Karasaki H, Furukawa H., Yoneda M. Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats. Life Sci. 2012 90:122-130. 93. Kono T, Satomi M, Suno M, Kimura N, Yamazaki , Furukawa H, Matsubara K. Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation Brain Behav 2012 2(1):68-73.

94. Fischera A, Zoccali M, Kono T. Antimesenteric functional end-to-end handsewn (Kono-S) anastomosis. J Gastrointest Surg 16(7),1412-1416, 2012

95. Ito T, Tanabe H, Ayabe T, Ishikawa C, Inaba Y, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y. Paneth cells regulate both chemotaxis of immature dendritic cells and cytokine production from epithelial cells. Tohoku J Exp Med. 2012;227(1):39-48

96. Nozakia, R, Tamura S, Ito A, Moriyama T, Yamaguchi K, Kono T A rapid method to isolate soluble royal jelly proteins Food Chem 201210.1016/j.foodchem.2012.03.106

97. Yamaguchi K, Kono T, Satomi M, Murata K, He S, Li Z: Effect of moisturizing cream containing honey on epidermal growth factor receptor inhibitor-induced dermatologic toxicities in patients with advanced colorectal cancer. Pharmacometrics, 83(3/4): 17-22 (2012)

98. 河野 透、高後 裕 、アレサンドロフィケラ、大毛宏喜、坂井義治、前田耕太郎 達人こだわりの手術テクニック クローン病腸管の吻合術 手術 66(10), 1355-1360, 2012

99. 河野 透、岡本耕太郎、高後 裕 Crohn病腸管手術の新たな標準術式となる可能性と現状:Kono-S吻合消化器内視鏡24(2),251-257,2012

100. 河野 透、上園 保仁 腸管血流からみた大建中湯の役割 アメリカ臨床治験薬TU-100になった理由 医学のあゆみ 241(2),163-169,2012

101. 河野 透、荒川 哲男、鳥羽研二 機能性消化器疾患の変遷とその治療-複合的な症状にどう対処するか:漢方の役割 50(8), 965-975, 2012

102. 掛地吉弘、河野 透 EBMによるがん領域の漢方の使い方2012 ライフ・サイエンス出版

103. 河野 透 著書名:がん漢方 2012 今日のがん治療を支える漢方薬のエビデンス 南山堂出版 pp.16-25

104. Kono T, Ashida T, Ebisawa Y, Chisato N, Okamoto K, Katsuno H, Maeda K, Fujiya M A new antimesenteric functional end to end hand-sewn anastomosis. Surgical prevention of anastomotic recurrence in Crohn's disease. Dis Colon Rectum 54(5), 586-592, 2011

105. Kono T, Kashiwade Y, Asama T, Chisato N, Ebisawa Y, Yoneda M, Kasai S.  Preventive effect of urinary trypsin inhibitor on the development of liver fibrosis in mice. Exp Biol Med (Maywood). 2011 236(11):1314-21.

106. Kono T, Omiya Y, Hira Y, Kaneko A, Chiba S, Suzuki T, Noguchi M, Watanabe T. Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model. J Gastroenterol. 2011 46(10):1187-96.

107. Munekage M, Kitagawa H, Ichikawa K, Watanabe J, Aoki K, Kono T, Hanazaki KPharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteers. Drug Metab Dispos. 2011 39(10):1784-8.

108. Nishioka M, Shimada M, Kurita N, Iwata T, Morimoto S, Yoshikawa K, Higashijima J, Miyatani T, Kono T. The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen. Int J Clin Oncol 2011 16(4):322-7.

109. Karasaki H, Mizukami Y, Tokusashi Y, Koizumi K, Ishizaki A, Imai K, Yoshikawa D, Kino S, Sasajima J, Tanno S, Matsumoto K, Miyokawa N, Kono T, Kohgo Y, Furukawa H. Localization of the most severely dysplastic/invasive lesions and mucin phenotypes in intraductal papillary mucinous neoplasm of the pancreas. Pancreas. 2011;40(4):588-94. 110. Kashima S., Nata T., Fujiya. M, Moriichi K., Nomura Y., Ueno N., Itabashi K., Ishikawa C., Inaba Y., Ito T., Okamoto K., Mizukami Y., Ebisawa Y., Chisato N., Kono T., Tokusashi Y., Miyokawa N., Yamada M., Kohgo Y.; Obscure gastrointestinal bleeding from vascular lesions formed by venous and lymphatic congestion due to post-operative adhesion and subsequent mesenteric torsion 50 years after appendectomy Gut 2011 Oct;60(10):1344, 1403.

111. Miyamoto M, Ojima H, Iwasaki M, Hiraoka N, Kosuge T, Yoshikawa D, Kono T, Furukawa H, Shibata T. Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. Br J Cancer 105 (1), 131-138, 2011

112. 河野 透 クローン病外科治療の新たな展開 グラフ 日本医事新報 4565, 67-72, 2011

113. 河野 透 今のクローン病治療に大建中湯が貢献できる可能性について 日本医事新報 一週一話 2011

114. 河野 透 漢方のCAMからの脱出:大建中湯を中心に 日薬理誌 137, 13-17, 20

115. 河野 透 漢方薬を駆使したがん治療の有害事象の緩和 日経メディカルCancer Review 12, 47-52, 2011

116. 河野 透 大建中湯のエビデンスと国際化 老年医学 49(6), 643-649, 2011

117. 河野 透 腸管粘膜血流に対する漢方の作用 消化器の臨床 14(3), 246-251, 2011

118. 河野 透 今のクローン病治療に大建中湯が貢献できる可能性について 日本医事新報 4548, 48-49, 2011

119. 河野 透 進歩する潰瘍性大腸炎治療 臨床のあゆみ 88, 15-16, 2011

120. Kono T, Satomi M, Asama T, Ebisawa Y, Chisato N, Suno M, Karasaki H, Furukawa H, Matsubara K. Cetuximab-induced hypomagnesaemia aggravates peripheral sensory neurotoxicity caused by oxaliplatin. J Gastrointest Oncology 1(2), 97-101, 2010.

121. Kono T, Satomi M, Chisato N, Ebisawa Y, Suno M, Asama T, Karasaki H, ,Matsubara K, Furukawa H. Topical application of hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis. World J Oncol 1(6), 232-235, 2010.

122. Kono T, Kaneko A, Hira Y, Suzuki T, Chisato N, Ohtake N, Miura N, Watanbe T ; Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse model. J Crohns Colitis, 2010;4:161-170, 2010.

123. Kono T. Endogenous calcitonin gene-related peptide and adrenomedullin are target peptides for Daikenchuto (Da-Jian-Zhong-Tang), an extracted traditional Japanese medicine-New possibility for Crohn's disease management- Basics of Evidences-Based Herval medicine, p123-138, editor H. Satoh, 2010

124. 河野 透 クローン病の外科的再発を防ぐ INTESTINE 14(5): 491-498, 2010

125. 河野 透 Crohn病小腸病変に対する治療効果 狭窄形成術の進歩 胃と腸 45(10): 1-6, 2010

126. 河野 透 クローン病に対する外科療法の進歩 日本消化器病学会雑誌 107(6): 876-884, 2010

127. 花井恒一、前田耕太郎、升森 宏次、勝野秀稔、河野 透 腸管吻合-手縫い吻合について 手術 64(10): 1483-1489, 2010

128. 河野 透 消化管血流と漢方 G.I. Research 18(4): 268-275, 2010

129. 河野 透 外科臨床に取り入れたい漢方治療とエビデンス 外科治療 103(6): 539-544, 2010

130. 河野 透 IBDの新しい術式 前編 CCJAPAN 58, 40-42, 2010.

131. 河野 透 IBDの新しい術式 後編 CCJAPAN 59, 46-48, 2010.

132. Sasajima J., Mizukami Y., Sugiyama Y., Nakamura K., Kawamoto T., Koizumi K., Fujii R., Motomura W., Karasaki H., Kono T., Bardeesy N., Chung D., Kohgo Y. Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduced hypoxia in tumors. Cancer Res. ;70(15):6283-6292, 2010

133. Kono T, Mishima H, Shimada M, Morita S, Sakamoto J; for the GONE investigators. Preventive Effect of Goshajinkigan on Peripheral Neurotoxicity of FOLFOX Therapy: A Placebo-controlled Double-blind Randomized Phase II Study (the GONE Study).Jpn J Clin Oncol. 39(12):847-9, 2009.

134. Kono T, Mamiya N, Chisato N, Ebisawa Y, Yamazaki H, Watari J, Yamamoto Y, Suzuki S, Asama T, Kamiya K Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer. Evid-Based Compl Alt, 2009 (in press) (doi:10.1093/ecam/nep200).

135. Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo YP; recursor Processing of Human Defensin-5 Is Essential to the Multiple Functions in vitro and in vivo. J Innate Immun 2(1):66-76, 2010.

136. Tamura S, Amano S, Kono T, Kondoh J, Yamaguchi K, Kobayashi S, Ayabe T, Moriyama T; Molecular characteristics and physiological functions of major royal jelly protein1 oligomer. Proteomics 9, 5534-5543, 2009

137. Kono T, Kanematsu T, Kitajima M. Exodus of Kampo, traditional Japanese medicine, from the complementary and alternative medicines: is it time yet? Surgery. 146(5):837-40, 2009.

138. Karasaki H, Mizukami Y, Ishizaki A, Goto J, Yoshikawa D, Kino S, Tokusashi Y, Miyokawa N, Yamada T, Kono T, Kasai S. Portal annular pancreas, a notable pancreatic malformation: frequency, morphology, and implications for pancreatic surgery. Surgery. 146(3):515-8, 2009

139. 河野 透、海老澤良昭、千里直之、山田理大 消化管症候群(第2版) その他の消化管疾患を含めて】 肛門 腫瘍 肛門未分化癌(解説/特集) 日本臨床 別冊消化管症候群(下) Page763-765(2009.09)

140. 田邊裕貴, 前本篤男, 綾部時芳, 伊藤貴博, 河野 透, 蘆田知史, 高後 裕 【炎症性腸疾患の新規治療を探る】 抗菌ペプチドによる消化管バリア療法の可能性は? 分子消化器病 6巻2号 Page133-139(2009.06)

141. 伊藤貴博, 綾部時芳, 上野伸展, 金野陽高, 石川千里, 盛一健太郎, 岡本耕太郎, 田邊裕貴, 前本篤男, 藤谷幹浩, 河野 透, 蘆田知史, 高後裕 消化器疾患における自然免疫・獲得免疫のクロストーク ヒトPaneth細胞分泌物による炎症反応の制御  消化器と免疫45号 Page34-38(2009.03)

142. 河野 透 建中湯類の有用性 大建中湯のエビデンスを求めて 基礎から臨床へ  小児疾患漢方治療 7巻 Page36-43(2008.03)

143. 河野 透, 千里直之, 海老澤良昭, 山田理大, 葛西眞一 Crohn病の新たな腸管切除・吻合術式 小児期での実施 小児外科(0385-6313)41巻3号 Page257-262(2009.03)

144. Tanabe H, Sato T, Watari J, Maemoto A, Fijiya M, Kono T, Ashida T, Ayabe T, Kohgo Y. Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomach. Helicobacter.13(5):370-9, 2008

145. Kono T., Koseki T., Chiba S., Ebisawa Y., Chisato N., Iwamoto J., Kasai S. Colonic Vascular Conductance Increased by Daikenchuto via Calcitonin Gene-Related Peptide and Receptor-Activity Modifying Protein 1. J Surg Res. 150, 78-84, 2008

146. Omiya Y., M.Yuzurihara,Y. Suzuki, Y. Kase, Kono T. Role of alpha2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice. Eur J Pharmacol. 592(1-3), 62-66, 2008.

147. Sato R., Wartari J., Tanabe H., Fujiya M., Ueno N., Ashida T., Kono T., Kohgo Y. Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction.

Gastrointest Endosc. 67(6):953-957, 2008 148. Yamazaki M., Nakamura K., Mizukami Y., Ii M., Kono T., Fujiya M., Ashida T., Chung DC., Kohgo Y. Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells. Cancer Sci. 99(6):1131-1138, 2008

149. Maruyama H., Ishii S., Shimotori M., Kameda S., Kono T., Miyazaki J., Kulkarni A.B., Gejyo F. Naked Plasmid DNA-Based a-Galactosidase A Gene Transfer Partially Reduces Systemic Accumulation of Globotriaosylceramide in Fabry Mice Gen Nakamura1, Mol. Biotechnol. 38(2):109-119, 2008

150. Itabashi M., Ikeuchi H., Araki T., Kono T., Nakamura T., Kakesue Y., Kameoka S., Kusunoki M. Effectiveness of leukocytapheresis in suppressing the occurrence of surgical site infections following surgery for ulcerative colitis. Surg Today. 38(7):609-617, 2008

151. 河野 透、葛西眞一 漢方と消化管血流 臨床外科 63巻4号 Page463-471(2008.04)

152. 河野 透 大建中湯の腸管血流量に及ぼす影響 産婦人科 漢方研究のあゆみ 25巻 Page27-34(2008.04)

153. Tanabe H., Ayabe T., Maemoto A., Ishikawa C., Inaba Y., Sato R., Moriichi K., Okamoto K., Watari J., Kono T., Ashida T., Kohgo Y. Denaturated human defensin attenuates the bactericidal activity and the stability against enzymatic digestion. Biochem Bioph Res Co 358, 349-355, 2007

154. 河野 透 大建中湯のエビデンスを求めて 小児疾患の身近な漢方治療 7, 36-43, 2007

155. Kono T., Ebisawa Y., Tomita I., Chisato N., Kamiya K., Asama T., Ayabe T., Kohgo Y., Kasai S. Phase II study of irinotecan, leucovorin, 5-fluorouracil, and tegafur/uracil for metastatic colorectal cancer (MCRC) J Chemotherpy 17(2), 224-227, 2005

156. Yoneda M., Kono T., Watanobe H., Tamano M., Shimada T., Heraishi H., Nakamura K. Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats. Peptides. 26(9), 1573-1579, 2005

157. Yoneda M., Nakamura K., Nakade Y., Tamano M., Kono T., Watanobe H., Shimada T., Hiraishi H., Terano A. Effect of central corticotropin-releasing factor on hepatic circulation in rats: a role of CRF2 receptor in the brain. Gut 54(2), 282-288, 2005

158. Maruyama H., Higuchi N., Kameda S., Nakamura G., Shimotori M., Iino N., Higuchi M., Neichi T., Yokoyama S., Kono T., Miyazaki J., Gejyo F. Sustained transgene expression in rat kidney using naked plasmid DNA and PCR-amplified DNA fragments J Biochemistry 137(3), 373-80, 2005

159. Yoneda M., Manabu G., Nakamura K., Yokohama S., .Kono T., Tamano M., Shimada T., Heraishi H., Thyrotropin-releasing hormone in the dorsal complex stimulates pancreatic blood flow in rats. Regul Peptides 26(9), 1573-1579, 2005

160. 綾部時芳,蘆田知史、河野 透、高後 裕 腸粘膜上皮におけるPaneth細胞の自然免疫機能と病原体認識機構 Annual Review 免疫(中外医学社)編集 奥村 康, 平野俊夫、佐藤昇志、81-87, 2005

161. Ayabe T., Ashida T., Kohgo Y., Kono T. The roles of intestinal Paneth cells and their antimicrobial peptides in innate host defense Trends Microbiol. 12(8), 394-398, 2004.

162. Ebisawa Y., Kono T., Yoneda M., Asama T., Chisato N., Sugawara M., Ishikawa K., Iwamoto J., Ayabe T., Kohgo Y., Kasai S. Direct evidence that induced nitric oxide in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats. J Surg Res 118(2), 183-189, 2004.

163. Kono T., Chisato N., Ebisawa Y., Asama T., Sugawara M., Yoneda M., Ayabe T., Kohgo Y., Kasai S., Takahashi T. .Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bio-imaging system J Surg Res 117(2), 329-338, 2004.

164. Kono T, Tomita I, Chisato N, Matsuda M, Kakisaka A, Kasai S. Successful Low-Dose Chemotherapy Using Vinblastine and Methotrexate for the Treatment of an Ileoanal Pouch Mesenteric Desmoid Tumor: Report of a Case. Dis Colon Rectum 47(2), 246-249, 2004.

165. Yoneda M, Hasegawa T, Nakamura K, Tamano M, Kono T, Terano A. Vitamin E therapy and plasma cytokines in patients with NASH. Hepatology 39(2):568, 2004.

166. Yoneda M, Hashimoto T, Nakamura K, Tamori K, Sato Y, Yokohama S, Kono T, Watanobe H, Terano A. Thyrotropin-releasing hormone in the dorsal vagal complex stimulates hepatic blood flow in rats. Hepatology 38, 1500-1507, 2003.

167. Yoneda M, Sato Y, Nakamura K, Yokohama S, Kono T, Watanobe H, Terano A. Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection. Eur. J. Pharmacol. 478(2-3), 173-177, 2003.

168. Ohara K., Kono T., Chisato N., Asama T., Yoneda M., Kasai S. Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenase. Int. J. Colorectal. Dis. 18(3): 260-266, 2003.

169. Nakade Y., Yoneda M., Kono T., Terano A. Central injection of a novel corticotropin-releasing factor antagonist, astressin, inhibits carbon tetrachloride induced acute liver injury in rats. Eur. J. Pharmacol. 460: 135-138, 2003.

170. Takahashi T., Matsuda K., Kono T., Pappas TN. Hyperglycemia inhibits neural activity of vagus in rats. Intensive Care Med. 29: 309-311, 2003.

171. Kono T., Kotani H., Asama T., Mamiya N., Ohara K., Yoneda M., Iwamoto J., Kasai S. Protective effect of pretreatment with low-dose lipopolysaccharide on D-galactosamine-induced acute liver failure. Int. J. Colorectal. Dis. 17(2): 98-103, 2002.

172. Kono T., Kotani H., Asama T., Mamiya N., Ohara K., Yoneda M., Iwamoto J., Kasai S. Adaptive cytoprotection against acetic acid-induced colonic injury in rat. Int. J. Colorectal. Dis. 16(6), 384-390, 2001.

173. Kono T., Nishida M., Inagaki N., Tanaka Y., Yoneda M., Kasai S. 2001 Development and characterization of 1C6-203, a new monoclonal antibody specific to the human thymidine phosphorylase. J. Histochem. Cytochem. 49(1): 131-138, 2001.

174. Kono T., Nomura M., Kasai S., Kohgo Y. Effect of ecabet sodium enema on mild to moderate active ulcerative proctosigmoiditis: An open study. Am. J. Gastroenterol, 96(3): 793-797, 2001.

175. Kono T., Yoneda M., Ohara K., Ayabe T., Chisato N., Kohgo Y., Kasai S., Terano A., Tach Y. Adaptive cytoprotection against acetic acid-induced colonic injury in rats. Int J Colorectal Dis. 16: 384-390, 2001

176. Yokohama S., Yoneda M., Watanobe H., Kono T., Nakamura K., Makino I., Terano A. Effect of central urocortin on carbon tetrachloride-induced acute liver injury in rats. Neurosci. Lett. 313(3): 149-52, 2001.

177. Kamiya K, Kono T, et al. The cytoprotective role of lipopolysaccharide-induced nitric oxide against liver damage during early phase of endotoxemia in rats. Shock 14: 229-233, 2000.

178. Tamori K, Yoneda M, Kono T, et al. Role of calcitonin gene-related pepide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia. Eur. J. Pharmacol. 380: 31-35, 1999.

179. Kono T, Yamamoto Y, et al. Adenosquamous carcinoma with endocrine cell differentiation of the rectum: report of a case. Dis Colon Rectum 42: 1089-92, 1999.

180. Ando N, Kono T, et al. Nitric oxide release from the liver surface to the intra-abdominal cavity during acute endotoxemia in rats. Nitric Oxide-Biol Ch 2: 481-488, 1998.

181. Yoneda M, Nakamura K, Kono T, et al. Neuropeptide Y stimulates bile secretion via Y1 receptor in the left dorsal vagal complex in rats. Hepatology 28: 670-676, 1998.

182. Kono T, Miyata M, et al. Pelvic nerve grafts restore bladder function in denervated rats. Surgery 123: 672-678, 1998